Requirement of Oct3/4 function for germ cell specification
نویسندگان
چکیده
منابع مشابه
Germ Cell Specification Req
Background: Primordial germ cell (PGC) specification is a universal process across animals, but the molecular mechanisms specifying PGCs are remarkably diverse. In Drosophila, PGCs are specified bymaternally provided, asymmetrically localized cytoplasmic factors (germ plasm). In contrast, historical literature on most other arthropods reports that PGCs arise from mesoderm during midembryogenesi...
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Primordial germ cells are the progenitor cells that give rise to the gametes. In some animals, the germline is induced by zygotic transcription factors, whereas in others, primordial germ cell specification occurs via inheritance of maternally provided gene products known as germ plasm. Once specified, the primordial germ cells of some animals must acquire motility and migrate to the gonad in o...
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The aim of the present work is to introduce a pattern-based method for assisting the user during the temporal Requirement Specification (RS) phase. Indeed, since the user usually has to handle abstract notation as well as mathematical-based languages within this phase, RS is becoming more and more tedious and error-prone especially when dealing with complex systems. The authors’ method begins b...
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In C. elegans, the germ line is set apart from the soma early in embryogenesis. Several important themes have emerged in specifying and guiding the development of the nascent germ line. At early stages, the germline blastomeres are maintained in a transcriptionally silent state by the transcriptional repressor PIE-1. When this silencing is lifted, it is postulated that correct patterns of germl...
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BACKGROUND Primordial germ cell (PGC) specification is the first crucial step in germ line development. However, owing to significant challenges regarding the in vivo system, such as the complex cellular environment and potential problems with embryo manipulation, it is desirable to generate embryonic stem (ES) cells that are capable of overcoming these aforementioned limitations in order to pr...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2008
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2008.03.002